Resveratrol, a polyphenolic activator of the silent information regulation 2 homolog 1 (SIRT1), has been shown to extend the lifespan and improve metabolic disease. Other research has found that resveratrol inhibits ethanol-induced steatohepatitis in rats, due to its antioxidant properties. Steatohepatitis is liver disease characterized by inflammation with concurrent fat accumulation. Two of the negative consequences associated with the current obesity epidemic are development of hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). With this information in mind, Korean researchers investigated the possible beneficial effects of resveratrol on hepatic gene expression, lipid content, lipid profiles, and non-alcoholic steatohepatitis (NASH) on mice fed an atherogenic (Ath) diet (Ahn et al, 2008).
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